Trial failures of anti-inflammatory drugs in depression
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چکیده
منابع مشابه
Anti-Inflammatory Activity of a Selection of Antidepressant Drugs
Anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. In this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory d...
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Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
متن کاملAnti-inflammatory drugs in psychiatry.
Nervous and immune system interact through many different messenger substances such as neurotransmitters, cytokines or neuropeptides. For instance, neuropeptides are capable of affecting the metabolism of cells belonging to the immune system. Conversely, cytokines such as tumor necrosis factor (TNF)-alpha, interferon (IFN)-alpha and IFN-gamma, contribute to the receptor resistance of neuropepti...
متن کاملQSAR of anti-inflammatory drugs
The computer analysis of relations between molecular structures and their biological activity using fragmentbased methods is very useful to draw conclusions for the understanding of drug action and for the development of more efficient non-toxic drug candidates. We used the computer system SARD-21 (Structure Activity Relationship & Design) to investigate common structural features (fragments an...
متن کاملIsobolographic antinociception of non-steroidal anti-inflammatory drugs in rodent formalin orofacial pain
Diverse studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception through inhibition of cyclooxygenases. In this study was evaluated the effect of NSAIDs to induce antinociception either alone or in combination in the formalin orofacial test of rodent. Male mice were injected intraperitoneally with dexibuprofen, dexktoprofen, diclofenac meloxicam, metamizol, and...
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ژورنال
عنوان ژورنال: The Lancet Psychiatry
سال: 2020
ISSN: 2215-0366
DOI: 10.1016/s2215-0366(20)30357-6